whole genome sequencing: an efficient approach in food safety management system

Whole Genome Sequencing: An Efficient Approach in Food Safety Management System

Whole Genome Sequencing Introduction to the Interpretation of Whole Genome Sequence Data in Food Safety

I ntroduction Whole genome sequencing (WGS) for bacterial foodborne pathogen characterization is here to stay. Developments in WGS platforms have made it possible to sequence the entire genome of bacteria at prices comparable to common molecular subtyping methods. These data can provide nearperfect discrimination of bacterial isolates. While common molecular subtyping methods only interrogate s...

Technical meeting on the Impact of Whole Genome Sequencing on food safety management: Poster abstracts

Whole-genome sequencing for optimized patient management.

Whole-genome sequencing of patient DNA can facilitate diagnosis of a disease, but its potential for guiding treatment has been under-realized. We interrogated the complete genome sequences of a 14-year-old fraternal twin pair diagnosed with dopa (3,4-dihydroxyphenylalanine)-responsive dystonia (DRD; Mendelian Inheritance in Man #128230). DRD is a genetically heterogeneous and clinically complex...

EMAGEN: An Efficient Approach to Multiple Whole Genome Alignment

Following advances in biotechnology, many new whole genome sequences are becoming available every year. A lot of useful information can be derived from the alignment and comparison of different genomes. However, most of the current research focuses on pairwise genome alignment, and only a few available applications can efficiently align multiple genomes. In this paper, we present an efficient a...

Whole-Genome Restriction Mapping by “Subhaploid”-Based RAD Sequencing: An Efficient and Flexible Approach for Physical Mapping and Genome Scaffolding

Assembly of complex genomes using short reads remains a major challenge, which usually yields highly fragmented assemblies. Generation of ultradense linkage maps is promising for anchoring such assemblies, but traditional linkage mapping methods are hindered by the infrequency and unevenness of meiotic recombination that limit attainable map resolution. Here we develop a sequencing-based "in vi...